​Blair was born Selma Blair Beitner in Southfield, Michigan, the daughter of Molly Ann, a judge, and Elliot Beitner. She has three older sisters, Katherine (a book publicist), Elizabeth, and Marie. Blair attended Hillel Day School, a Jewish day school in Farmington Hills, Michigan, and Cranbrook Kingswood school in Bloomfield Hills, Michigan. She attended Kalamazoo College in Michigan, then later transferred to the University of Michigan, where she earned her bachelor's degree in 1994. After training at the Stella Adler Conservatory of Acting, Blair began acting in the mid-90s. Blair began her career with small roles and guest roles in various television series. Blair appeared with co-stars Sarah Michelle Gellar, and Ryan Phillippe in the 1999 film Cruel Intentions , for which Blair won an MTV Movie Award for Best Kiss - Lesbian Kiss between Blair and co-star Gellar. Blair went on to star as Zoe Bean in two seasons of TV series Zoe, Duncan, Jack and Jane (1999-2000), She rejoined actress Reese Witherspoon in the comedy film Legally Blonde (2001). Later, Blair appeared in Highway (2002). She also starred opposite Cameron Diaz and Christina Applegate in The Sweetest Thing and in two independent films that garnered her much critical acclaim: Dana Lustig's Kill Me Later and Todd Solondz's controversial Storytelling, and one of her most recognized roles, Liz Sherman in Hellboy (2004) and its successful sequel released in 2008, Hellboy II: The Golden Army based on the popular comic. Other films include the political thiller The Deal, The Big Empty, Feast of Love (opposite Greg Kinnear and Morgan Freeman), Ed Burn's Purple Violets and the horror thriller W?Z (opposite Stellan Skarsgard). Blair starred opposite Molly Shannon in the TV series Kath & Kim, based on the Australian television series of the same name. Blair's upcoming projects are Happy Together (2009), as Mrs. Delbo, Columbus Circle (2010) and Different Kind Of Love (2011) with Juliette Lewis . Selma can also be seen in the My Friend Steve 1998 music video Charmed . Her stage work includes the role of Kayleen in Rajiv Joseph's Gruesome Playground Injuries, which had its world premiere at Houston's Alley Theatre in October 2009.

Blair nasceu Selma Blair Beitner em Southfield, Michigan, filha de Molly Ann, juiz e Elliot Beitner. Ela tem três irmãs mais velhas, Katherine (uma publicista do livro), Elizabeth e Marie. Blair frequentou Hillel Day School, uma escola de dia judaica em Farmington Hills, Michigan, e a escola Cranbrook Kingswood em Bloomfield Hills, Michigan. Ela freqüentou o Kalamazoo College em Michigan, depois transferiu-se para a Universidade de Michigan, onde obteve o diploma de bacharel em 1994. Após o treinamento no Stella Adler Conservatory of Acting, Blair começou a atuar em meados dos anos 90. Blair começou sua carreira com pequenos papéis e papéis convidados em várias séries de televisão. Blair apareceu com as co-estrelas Sarah Michelle Gellar e Ryan Phillippe no filme Cruel Intentions de 1999, para o qual Blair ganhou um Prêmio MTV Movie para Best Kiss - Lesbian Kiss entre Blair e co-estrela Gellar. Blair passou a estrela como Zoe Bean em duas temporadas da série de TV Zoe, Duncan, Jack e Jane (1999-2000). Ela reencontrou a atriz Reese Witherspoon no filme comédia Legally Blonde (2001). Mais tarde, Blair apareceu na Highway (2002). Ela também estrelou em frente a Cameron Diaz e Christina Applegate em The Sweetest Thing e em dois filmes independentes que conquistaram sua grande aclamação da crítica: Dana Lustig's Kill Me Later e Todd Solondz's Storytelling controverso, e um dos seus papéis mais reconhecidos, Liz Sherman in Hellboy (2004 ) e sua sequela bem sucedida lançada em 2008, Hellboy II: The Golden Army com base no popular quadrinho. Outros filmes incluem o Thiller político The Deal, The Big Empty, Feast of Love (oposto a Greg Kinnear e Morgan Freeman), as violetas roxas de Ed Burn e o thriller de terror W? Z (oposto a Stellan Skarsgard). Blair estrelou em frente a Molly Shannon na série de TV Kath & Kim, com base na série de televisão australiana do mesmo nome. Os próximos projetos de Blair são Happy Together (2009), como Mrs. Delbo, Columbus Circle (2010) e Different Kind of Love (2011) com Juliette Lewis. Selma também pode ser visto no video musical My Friend Steve 1998 Charmed. O seu trabalho em palco inclui o papel de Kayleen nas lesões de recreio do Rajiv Joseph, que teve sua estréia mundial no Alley Theatre de Houston, em outubro de 2009.

Pochodzi z Southfield w Michigan. Jest znana z roli głównej w filmie "Szkoła uwodzenia", będącym współczesną adaptacją klasycznej powieści "Niebezpieczne związki" . Scenarzystą i reżyserem tego filmu był Roger Kumble. Rola Cecile przyniosła jej doskonałe recenzje i nagrodą MTV Movie Award w kategorii najlepszego pocałunku (jej partnerką była Sarah Michelle Gellar). Za tą samą rolą nominowano ją także do tej samej nagrody w kategorii najlepszego debiutu. Zdobyła też nagrodą Movieline Magazine Award dla najlepszego nowego aktora. Po ukończeniu liceum Selma chciała zostać fotografem. Chcąc zrealizować swoje marzenia przeprowadziła się do Nowego Jorku, zainteresowała się jednak aktorstwem – zaczęła się uczyć w The Stella Adler Conservatory and The Column Theatre. Wkrótce zainteresował się nią pewien agent i tydzień póżniej zadebiutowała w telewizyjnej reklamówce Theater of Virginia. Selma występowała w głównej roli w dwóch seriach serialu "Zoe". Na ekranie kinowym wystąpiła w niezależnym filmie "Kill Me Later" wyreżyserowanym przez Daną Lustig. Wystąpiła także w przeboju "Legalna blondynka", w którym zagrała u boku Reese Witherspoon; pojawiła się także w filmie "Storytelling" reżysera Todda Solondza (Welcome To The Dollhouse, Happiness) oraz w "Ostrożnie z dziewczynami".

Selma Blair, duygusal-dram-komedi tarzı yapımlarda rol almış olan bir Amerikalı oyuncudur. En iyi bilinen rolleri Cecile Caldwell karakterini, canlandırdığı Cruel Intentions ve Vivian karakteriyle Legally Blonde adlı yapımlardır. Oyuncu Selma Blair Southfield, Michigan doğumludur.